Erythropoiesis in preleukemia

Erythropoiesis in preleukemia.

Bone marrow cells from seven patients with preleukemia and two with erythroleukemia were cultured in vitro to characterize erythropoiesis and erythropoietin responsiveness in these disorders. The methylcellulose plate technique was used to clone erythroid progenitors, and the results were compared to data obtained from studies on five healthy volunteers. Erythroid colonies formed in cultures fr...

Preleukemia in experimental leukemogenesis.

The long latent period characteristic for both spontaneous and induced murine leukemias may reflect multiple steps in the leukemogenic process. The induction of pre leukemia represents the initial phase in leukemogenesis. A sequence of further events (that could differ qualitatively from the initiating factor) is often required for the completion of the neoplastic transformation. The presence o...

Cellular maturation in human preleukemia.

Bone marrow cells from three preleukemic patients with prominent marrow karyotypic abnormalities were studied in liquid culture to determine if the neoplastic clones were capable of maturation. Parallel cytogenetic and cytologic studies were performed in sequentially harvested bone marrow cultures. Maturation, albeit delayed, occurred in cultures from all three patients. By 14 days of culture i...

Recognition of preleukemia.

Preleukemia, which can only be diagnosed retrospectively with certainty, presents multiple findings and clinical data which contribute to a pattern recognition process. The development of cytogenetic and marrow culture studies has not only provided additional criteria for diagnosis but also better indices of prognosis. Preleukemia can be considered to be an early expression of neoplastic diseas...

Myeloid dysplasia: the histopathology of preleukemia.